GRK 1673: Functional Molecular Infection Epidemiology

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Research Concept

Functional Molecular Infection Epidemiology – a new interdisciplinary approach

The research theme of the IRTG “Functional Molecular Infection Epidemiology” aims toward the integration of expertise in the field of Infection Biology in Berlin, and Bioinformatics in Hyderabad, to create the needed functional link between host-pathogen genomics, and the variation of host response to vital pathogens. Thus genetic variations may be linked to a unique function crucial for disease susceptibility, severity and progression.

The IRTG team will comprise of senior faculty members from different areas of infection biology who will come together to study various important infections that pose a threat to public health. Diseases like tuberculosis are a major public health concern, not only in India, but also globally due to the resurgence of the disease and the development of drug-resistant strains. Infections with mycobacteria other than tuberculosis are increasing worldwide and are now considered as emerging diseases. Moreover, pneumonia caused by S. pneumoniae and other pathogens is a leading cause of mortality and death in both Europe and India. The same applies to other bacterial and parasitic infections. There is a great need therefore, for a cooperative and multi-disciplinary approach in order to better understand the adaptation of the pathogen with respect to its specific geographical location, and its interaction with the host including strategies to evade the innate immune system. This will help to identify and design novel molecular intervention strategies. The pathogens of interest herein include bacterial pathogens causing important diseases like tuberculosis, lymphadenopathy, pneumonia, gastric disease, urinary tract infection, newborn meningitis and other extraintestinal infections, and parasitic pathogens that cause malaria and filariasis. In this manner, a broad range of clinically relevant organisms have been included in the scientific program of the IRTG.

 

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